The lab is back open! We're socially distancing, but finally getting some experiments done after nearly three months of COVID-19 shutdown.
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06/11/2023
06/09/2023
sgreen官网安卓 was selected to receive a prestigious Van Maanen Fellowship from the Department of Biological Chemistry and Molecular Pharmacology for academic year 2021. Made possible by the bequest of Evert F. Van Maanen, PhD, 1949, to Harvard Medical School, this fellowship is given to graduate students who have demonstrated excellence in their graduate studies and have shown great potential for a successful post-graduate career. The award provides a stipend for 12 months. Congratulations, Inwha!!
06/03/2023
Our first single molecule paper with the 安卓ssr官网 is now on Bioarxiv! Co-first authors Grace Rosen and Inwha Baek watch RNA polymerase II and Spt5 during the assembly of initiation complexes and transition to elongation.
05/01/2023
Our paper describing how Set1/COMPASS interacts with the RNA polymerase CTD is now in Nature Communications. Congratulations to first author Hyun Jin Bae and contributing author Jongcheol Jeon! Together with the labs of Vincent Geli and Jaehoon Kim, we showed that the combination of the Set1 N-terminal region and Swd2 create the CTD binding site.
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The Buratowski lab studies mechanisms of eukaryotic gene expression, focusing on RNA polymerase II transcription initiation, elongation, and termination, as well as the co-transcriptional processing of mRNA. We use a wide array of approaches, including classic molecular genetics, genomics, protein biochemistry, mass spectrometry, and single molecule microscopy.
Current projects include:
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Coupling of mRNA processing to transcription via phosphorylation of the RNA polymerase II C-terminal domain (CTD)
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The interplay between transcription and chromatin modifications, especially methylations of histone H3
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The role of overlapping non-coding RNA transcription in modifying mRNA expression
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The proteomics of transcription initiation and elongation (in collaboration with Jarrod Marto, DFCI/HMS)
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Single molecule studies of RNA polymerase II transcription (in collaboration with Jeff Gelles, Brandeis University)
SOME LAB MOVIES:
Video: Steve talks about the lab's research on gene expression at the sgreen加速器官网:2021-5-29 · sgreen加速器 苹果下载 安卓 下载 sgreen加速器安卓版 版本号：1.1.1 时间：06-11 下载 sgreen加速器 安卓版 版本号：1.1.2 时间：06-09 下载 sgreen加速器 苹果版 版本号：1.1.1 时间：06-11 ...
Video: A movie celebrating many years of Robin's cakes for lab birthdays, graduations, etc.!
